Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.752967
Title: Developing biomaterials through enhancing organic/inorganic interfaces
Author: Hughes, Erik Andreas Bjørnstad
ISNI:       0000 0004 7426 0745
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2018
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Abstract:
The socioeconomic demand for biomaterials has never been greater. Formulation at the organic/inorganic interface of materials has enabled the conception of several biomaterial systems for bone healing. In Chapter 2, a poly( ether ether ketone) (PEEK) and calcium sulphate (CS) composite is formulated. Inclusion of the polymer slowed CS degradation and augmented the mechanical properties significantly. Chapters 3 and 4 explore the formation mechanism of tubular calcium phosphate structures from a gel/solution interface. Both the composition and microstructure of tubules were analogous to features of bone. To demonstrate the bone graft application of these structures, a model bone defect was augmented with particles that could generate tubular calcium phosphate in the presence of tissue. 3D computed tomography reconstructions revealed bone-like mineral deposition throughout the cavity. Chapter 5 explores the chemical coupling of hydroxyapatite particles within a PEEK matrix, a composite that may be used to fabricate spinal fusion devices. Physical properties of composites were improved by a reduction in HA debonding, the presence of fewer micro cracks, and more effective load transfer between phases. Together, the research puts forward a novel collection ofbiomaterials that may be applied to the treatment of bone fractures and fusion of the spine.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (D.Eng.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.752967  DOI: Not available
Keywords: QH301 Biology ; T Technology (General)
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