Large-scale complex systems have large numbers of variables, network structure of interconnected subsystems, nonlinearity, spatial distribution with several time scales in its dynamics, uncertainties and constrained. Decomposition of large-scale complex systems into smaller more manageable subsystems allowed for implementing distributed control and coordinations mechanisms. This thesis proposed the use of distributed softly switched robustly feasible model predictive controllers (DSSRFMPC) for the control of large-scale complex systems. Each DSSRFMPC is made up of reconfigurable robustly feasible model predictive controllers (RRFMPC) to adapt to different operational states or fault scenarios of the plant. RRFMPC reconfiguration to adapt to different operational states of the plant is achieved using the soft switching method between the RRFMPC controllers. The RRFMPC is designed by utilizing the off-line safety zones and the robustly feasible invariant sets in the state space which are established off-line using Karush Kuhn Tucker conditions. This is used to achieve robust feasibility and recursive feasibility for the RRFMPC under different operational states of the plant. The feasible adaptive cooperation among DSSRFMPC agents under different operational states are proposed. The proposed methodology is verified by applying it to a simulated benchmark drinking water distribution systems (DWDS) water quality control.