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Title: Blood clot microstructures : the role of engineered and combustion derived carbon particulates in thrombus formation
Author: Puckering, Oliver James
Awarding Body: Swansea University
Current Institution: Swansea University
Date of Award: 2009
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This thesis deals with assessment of effects on thrombus structure brought about by the addition of carbon nanoparticles to blood in vitro. Chapter 1 outlines the development of the rheological discipline and discusses viscoelastic systems. Whole blood is a transient viscoelastic system. Methods of locating the point of this change, the gel point, are discussed and briefly evaluated. In Chapter 2 the development of fractal analysis is investigated and the method by which a phase angle measured at the gel point can be converted into a fractal dimension is outlined. Carbon nanoparticles are discussed in Chapter 3 along with their methods of generation and an outline of the research into any associated health effects which has been carried out. The means by which the nanoparticles, both individually and in suspension, can be assessed are outlined in Chapter 4. Tests which were carried out to determine the best solvent for this work are outlined and the results discussed. Chapter 5 concerns blood and the cardiovascular system. The means by which thrombus generation and removal occur are discussed together with the TEG and Sonoclot clinical systems used to analyse haemostasis. Chapter 6 states the hypotheses to be investigated in this work. In Chapter 7 the materials and methods for the production of suspensions, their inclusion into extracted whole blood and the measurements taken on the resulting blood sample are outlined. Chapters 8-12 present the results from each of the nanoparticles investigated. Chapter 13 presents the conclusions drawn from the comparison of the results and discussions in Chapters 8-12. The most important of these conclusions is the order of effect of the nanoparticles on the blood: MCOOH > SCOOH > LPMN > LPSN > DIESEL.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available