Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.749430
Title: Ruthenium and copper complexes for anti-cancer and catalytic applications
Author: Madzivire, Cecilia Rutendo
ISNI:       0000 0004 7233 7139
Awarding Body: University of Leeds
Current Institution: University of Leeds
Date of Award: 2018
Availability of Full Text:
Access from EThOS:
Access from Institution:
Abstract:
This thesis details the synthesis, characterisation and evaluation of novel β-bis-ketoiminate ruthenium(II) and β-bis-ketoiminate copper(II) complexes for their biological and chemical applications. The anti-cancer, anti-bacterial and anti-fungal and catalytic activity of these complexes was investigated, with lead complexes undergoing further mechanistic investigations. Chapter 1 contains the background introduction to the project, through literature research of similar work as well as the aims of this project. Chapter 2 presents the synthesis and characterisation of novel β-bis-ketoiminate ruthenium(II) dicarbonyl complexes. 1H NMR, 13C {1H} NMR and detailed X-ray crystallographic data are given for this series of complexes. Chapter 3 introduces novel β-bis-ketoiminate copper(II) complexes, their synthesis and characterisation, with X-ray crystallographic data discussed. Chapter 4 introduces the MTT technique for assessing cytotoxicity, and discusses the anti-cancer activities of the series of complexes synthesised in Chapters 2 and 3. In addition, the chapter gives a brief literature review to anti-bacterial and anti-microbial studies, and the results of anti-bacterial and anti-fungal investigations on the β-bis-ketoiminate ruthenium(II) and copper(II) complexes. Chapter 5 presents the results of chemical investigations, hydrolysis and biomembrane, conducted on the two libraries of complexes. Chapter 6 contains a brief literature review on catalysis, and the results for transfer hydrogenation and Ullmann catalytic reactions on β-bis-ketoiminate ruthenium(II) complexes and β-bis-ketoiminate copper(II) complexes respectively. Chapter 7 contains experimental details and characterisation data for all the complexes synthesised within this thesis, and protocols for all the biological and chemical studies. Appendix presents a summary of X-ray crystallographic structure analysis for all the crystal structures reported within this thesis.
Supervisor: McGowan, Patrick Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.749430  DOI: Not available
Share: