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Title: Synthesis of the EFG-ring system of pectenotoxin-4
Author: Roushanbakhti, Ahria Esphandiar
ISNI:       0000 0004 7232 2033
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2017
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The EFG-ring system of pectenotoxin-4 was synthesised via a novel pathway which ultilised a cobalt-mediated oxidative cyclisation to access the trans F-ring, and an osmium-mediated oxidative cyclisation to form the cis E-ring. Subsequent union of these fragments, under modified Julia-Kocienski olefination conditions, facilitated the synthesis of the EFG-ring system of pectenotoxin-4. Introduction This chapter reports the previous total syntheses of pectenotoxin molecules, along with completed syntheses of pectenotoxin fragments, including the Donohoe group's synthesis of the ABC-ring system of pectenotoxin-4. Results and Discussion The synthesis of the FG-ring system and subsequent coupling to the E-ring fragment are detailed in this chapter. The final steps from the Julia adduct to the EFG-ring system conclude this chapter.
Supervisor: Donohoe, Tim Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available