Two trends are currently driving the need for supply chain firms to form closely integrated relationships: collaboration and digitisation. One of the ways to achieve digitisation of supply chain operations is to implement Inter-Organisational Information Systems (IOIS) with selected supply chain partners for a much more efficient, streamlined and orchestrated supply chain operations. Whilst IOIS can be implemented to support various cross-functional business processes (ranging from operational information exchange to pursuing strategic initiatives such as sharing ideas, identifying new market opportunities, and pursing a continuous improvement approach), in the context of this thesis, the purpose of IOIS implementation is to facilitate the inter-firm procurement-related operations with downstream supply chain firms. The study undertaken in this research project was initiated in response to an industry requirement to investigate the implementation of IOIS against a backdrop of improved Supply Chain Management and integration practices by large contractor organisations. A case study research strategy was adopted to investigate the IOIS project related, IOIS (system) related issues encountered in ex-ante and ex-post implementation stages of the IOIS. The study concludes that it is the non-technical factors that are critical to the successful delivery of IOIS projects and provides a guideline on IOIS implementation by large contractor organisations. The findings of this research project have been published in a number of peer-reviewed papers.