Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.747827
Title: Studies in the chemistry of nitrogen heterocycles
Author: Tan, Seng-Leong
Awarding Body: Loughborough University of Technology
Current Institution: Loughborough University
Date of Award: 1970
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Abstract:
Cyanochlorination and cyanogenation of the hetero-ring of various isoquinolines has been achieved by reaction with sulphuryl chloride, with potassium cyanide at room temperature. Application of the method to the isoquinolines Reissert compound gave a chlorohydrin derivative which was more easily prepared by the action of hypochlorous acid. This chlorohydrin underwent novel rearrangement reactions on base-catalysed elimination of hydrogen chloride: an isochromene ring was first produced which rearranged further to generate a new isoquinoline system. Autoxidation of the anion derived from the isoquinoline Reissert compound was shown to give isoquinaldonitrile. The reaction of Nb-benzyltryptamine with formaldehyde has been studied and an improved preparation of Nb-methyltryptamine developed.
Supervisor: Not available Sponsor: Loughborough University of Technology
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.747827  DOI: Not available
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