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Title: Optimization and new applications of edge-illumination based X-ray phase contrast CT
Author: Zamir, Anna
ISNI:       0000 0004 7227 5185
Awarding Body: UCL (University College London)
Current Institution: University College London (University of London)
Date of Award: 2017
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The Edge Illumination (EI) method is a phase contrast imaging technique suitable for use with conventional X-ray sources, which has demonstrated its great potential for translation into real-world environments. The increase in image contrast provided by it, in particular for low-absorbing materials, along with its ability to be operated as a computed tomography (CT) modality, make it an especially advantageous technique for biomedical applications. The work presented in this thesis aimed to develop new image acquisition and processing strategies to further advance the current capabilities of EI CT, such that it could be used in a robust way for a wide range of biomedical applications. This was achieved by the development of two retrieval algorithms, which are required for the extraction of quantitative information of various sample properties. The first algorithm targets applications which involve high-resolution, multi-modal lab-based CT scans. It has been shown that, during these long scans, the variation in system parameters across the field-of-view and over time can lead to significant image artefacts in reconstructed CT slices. The proposed algorithm is capable of correcting for both types of variations, leading to the quantitative retrieval of sample properties from long CT scans in non-ideal environments. The second algorithm was aimed at applications which require fast CT scans, possibly at the expense of spatial resolution and quantitative information. A previously developed algorithm enabled a substantial reduction in scan times for homogeneous samples, by reducing the number of required images per angular view. The new algorithm presented here has extended the previous one to non-homogeneous samples, therefore expanding the range of objects which could benefit from a reduction in scan times through use of this approach. In addition, perinatal post-mortem imaging has been identified as a new biomedical application which could benefit from EI CT in the future. Promising results are reported from a proof-of-principle scan carried out using a gold standard X-ray phase contrast imaging method at a synchrotron.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available