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Title: Engineering solutions to the characterisation of clinical disorders of upper eyelid movement
Author: Mak, F. H.-W.
ISNI:       0000 0004 7226 681X
Awarding Body: UCL (University College London)
Current Institution: University College London (University of London)
Date of Award: 2017
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This project is about improving functioning in patients with ptosis associated with poor levator palpebrae superioris (LPS) function. LPS is a highly specialised muscle responsible for raising the eyelid. Defective LPS may cause the eyelid to droop uncontrollably, thereby covering the visual axis and affecting vision. The current method of correction relies heavily on the experience of the surgeon. Rarely, the implanted materials are at risk of exposure, infection, rejection. More commonly, the ability to completely shut the eyelids is impaired, leading to the danger of corneal exposure that can lead to severe pain and sight-threatening complications. Many patients will require repeat surgeries for correction in the future. One reason for such mechanical failure includes the lack of understanding of the mechanical characteristics of the muscle involved in blinking, and the current surgical suspension material used in replacing it. This lack of a scientific basis means that ptosis is a major challenge in ophthalmic surgery. The aim of this work will include analysing and characterising LPS and blinking dynamics, in the hope of improving future clinical procedures and perhaps provide insights on surgical materials. Two separate approaches are running in parallel to investigate blinking dynamics: to define the mechanical characteristics and properties of the muscles involved in blinking, a new apparatus was designed and constructed to measure the force in eyelid closure, particularly the maximum force of contraction and natural force of closure. On another aspect, a high-speed camera was used at Moorfields Eye Hospital to record and analyse blinking in 32 patients with ptosis, thyroid eye disease and Blepharospasm. The collected and analysed data are used to investigate how eye blinking dynamics in diseased patients are different from healthy individuals and to attempt to separate them from controls using a modelling system. In addition, the blinking dynamics of dermatochalasis patients before and after blepharoplasty surgery were also compared with healthy individuals using high-speed camera and later advanced statistical analysis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available