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Title: Development of a hydroxyapatite/POSS-PCU composite film for bone grafting and augmentation
Author: Salmasi, S.
ISNI:       0000 0004 7225 2477
Awarding Body: UCL (University College London)
Current Institution: University College London (University of London)
Date of Award: 2017
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The current approach towards treating critical size bone defects, with the aim of repairing or regenerating bone, is the use of bone grafts (autografts or allografts). However, due to various disadvantages associated with the use of autografts and allografts, biomaterials; synthetic ceramic/polymer composites as bone grafts substitutes and guided bone regeneration membranes in particular, have been recognised as effective alternatives to the traditional methods. Polyhedral oligomeric silsesquioxane covalently bonded to poly(carbonate- urea-urethane), (POSS-PCU), a novel co-polymer, has displayed improved physico-chemical and material-cell interaction properties, which have led to variety of investigations on clinical applications of this material such as in synthetic heart valve production, bypass grafts, POSS-PCU coated stents and biomaterial scaffolds. In this thesis, hydroxyapatite incorporated POSS-PCU composite films were developed and examined for the purpose of bone grafting and augmentation. Various concentrations of hydroxyapatite, filler integration and fabrication techniques as well as in vitro models were used to find the most suitable HA/POSS-PCU based composite film that has a closer characteristics to natural bone and enhances bone repair and new bone formation for bone grafting and augmentation applications. It was shown that hydroxyapatite has a concentration-dependent effect on the physico-chemical and material-cell interaction properties of POSS-PCU. In addition, it was shown that hydroxyapatite particles were exposed on the surface of the 50 wt% HA/POSS-PCU composite films and enhanced the bioactivity of these composite films in simulated body fluid. Finally, optimisation of the samples using surface solvent etching and porosity showed that the former increased surface hydrophobicity and reduced mechanical properties of both HA incorporated and HA free POSS-PCU films. Amongst all of the HA/POSS-PCU based composite films investigated here porous 50 wt% HA/POSS-PCU composites showed the most enhanced material-cell interaction properties. In conclusion, HA/POSS-PCU composites have the potential to be further investigated for bone augmentation as guided bone regeneration membranes.
Supervisor: Blunn, G. ; Loizidou, M. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available