Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.746247
Title: The impact of periodontal infection and its treatment on systemic inflammation, oxidative stress and endothelium integrity
Author: Orlandi, M.
ISNI:       0000 0004 7230 7001
Awarding Body: UCL (University College London)
Current Institution: University College London (University of London)
Date of Award: 2016
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Abstract:
Background: Periodontitis (PD) is a chronic inflammatory disease. The low-grade systemic inflammatory and oxidative status seems to be a plausible mechanism to explain the relationship between cardiovascular disease (CVD) and PD. The aim of this PhD was to investigate the association between PD and its treatment and the human vascular homeostasis. Methods: 4 studies were conducted: 1) a systematic review and meta-analysis of cases with PD and controls to assess the differences in intima-media thickness and endothelial function between cases and controls, 2) a Randomized controlled trial investigating the effect of periodontal therapy on mitochondrial oxidative stress, systemic inflammation, endothelial function and metabolic control in patients with type II diabetes mellitus and periodontitis 3) a randomized controlled trial investigating the effect of periodontal treatment on the carotid intima media thickness 4) a RCT controlled trial investigating the effect of remote ischemic preconditioning on the endothelial dysfunction following periodontal treatment. Results: Study I demonstrated that there is an association between PD, flow mediated dilation and carotid intima media thickness, measures of cardiovascular risk. Study II reported the benefit of periodontal therapy on the endothelial function, mitochondrial oxidative stress and glycemic control in patients with Type 2 diabetes and PD. In Study III we reported the beneficial effect of periodontal treatment on the carotid intima-media thickness and lastly in Study IV demonstrated the protective effect of remote ischemic preconditioning toward the acute endothelial dysfunction following periodontal treatment. Conclusions: This PhD project provides evidence in support of the association between periodontitis and cardiovascular disease.
Supervisor: D'Aiuto, F. D. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.746247  DOI: Not available
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