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Title: Experimental studies on tumour-inducing viruses of fowls
Author: Carr, J. G.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1947
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The investigations reported in the body of the thesis were initiated at the Lister Institute, London, in November 1937 in collaboration with Dr C.R. Amies, a special grant having been obtained from the British Empire Cancer Campaign for the specific study of fowl tumour viruses. The programme of the Lister was directed to the evolution of biochemical and biophysical techniques for the study of these viruses since such methods had proved their usefulness with plant viruses and vaccinia. Though the main requirement for such-techniaues, the rapid and easy production of large ouantities of virus, was successfully met, the association of large amounts of inert material of similar chemical and physical properties to the virus, previously unsuspected, limited the investigation to immunological methods (1). An interesting finding derived from this early study was the demonstration that the Des Ligneris sarcoma and the Fujinami sarcoma were indistinguishable; this was the more remarkable in view of the origin of the former from chemically treated tissue cultures, while the latter is a naturally occurring neoplasm (2). The fowls used for these researches were derived from the Brown Leghorn flock of Dr Greenwood, maintained at the Institute of Animal Genetics, Edinburgh. The varying susceptibilities of the individuals noted during the experiments were found from breeding data supplied by Dr Greenwood to have a genetic basis. A special grant was obtained to study this point, and this work was started in 1939. At this time Dr Amies was appointed to direct the Serum Department at Elstree, and ceased his connexion with the research programme. The investigations were resumed at the Institute of Animal Genetsics, Edinburgh. The different type of facilities here available resulted in a redirection of the work away from the chemical and physical aspects to a more biological viewpoint. The discovery of the recurring tumours led to the recognition of previously unsuspected carriers of tumour virus in fowls, and attempts were made to evaluate their importance as sources of infection in poultry flocks (3,8,11, 17).
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (D.Sc.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available