Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.742634
Title: Interactions between proteins and biomaterials : an experimental and computational multiscale study
Author: Liamas, Evangelos
ISNI:       0000 0004 7230 7618
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2018
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Abstract:
Understanding the interactions between proteins and biomaterials underpins the development of novel biomaterials that could produce a specific response towards the surrounding tissue, depending on the application. In this thesis, a combination of molecular dynamics (MD) simulations and experimental techniques was deployed to systematically study the effect of the biomaterial surface chemistry on the adsorption of proteins, and consequently the effect of proteins on the lifetime of a metallic biomaterial. It was found that the surface chemistry could have a significant impact on the protein adsorption process because it affects the adsorption kinetics, the driving forces of adsorption, the conformation of the adsorbed protein, and the functionality of the adsorbed protein. Furthermore, the adsorbed proteins could greatly affect the lifetime of a metallic biomaterial via tribocorrosion process where the biomaterial surface is subjected to friction.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.742634  DOI: Not available
Keywords: QR Microbiology ; TP Chemical technology
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