Use this URL to cite or link to this record in EThOS:
Title: Developments in magnetic resonance spectroscopic imaging acquisition and analysis
Author: Sawbridge, Rebecca Joanne
ISNI:       0000 0004 7230 3588
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2018
Availability of Full Text:
Access from EThOS:
Access from Institution:
Magnetic Resonance Spectroscopic Imaging (MRSI), a functional MR imaging technique, has proven via the identification of metabolite biomarkers to be useful in the diagnosis and prognosis of numerous diseases, for example brain tumours. However, a number of factors impede its routine clinical use: i) long acquisition times mean its use is limited to low resolution 2-dimensional slabs, ii) large quantity of data produced means its interpretation can be time consuming and iii) data quality can be variable and therefore interpretation can be difficult for a non-expert. Further developments in MRSI are designed to reduce the impact of these issues. The focus of this work is to address some of the above issues; developing acquisition protocols and optimising analysis methods in order to increase the clinical feasibility of MRSI. Within this study a fast-MRSI protocol has been developed for absolute metabolite quantitation and has demonstrated its feasibility for clinical use, accurately reproducing data in a shorter clinically feasible acquisition time. An experimentally derived fitting model has been developed which increases metabolite measurement accuracy. Finally, a 3D MRSI protocol has been successfully optimized allowing robust metabolite information to be mapped throughout the brain.
Supervisor: Not available Sponsor: Engineering and Physical Sciences Research Council (EPSRC) ; NIHR Professorship
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QD Chemistry ; RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry