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Title: Development of (Z)-alkenylsilane coupling methodology and application towards the synthesis of incednine
Author: Kuper, Christian J.
ISNI:       0000 0004 7229 9443
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2017
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This thesis describes the development of methods for the synthesis of incednam, the aglycon of incednine, via Hiyama cross-coupling. An early chapter discusses the efforts to improve upon previous efforts to access major building blocks. This is followed by a chapter focusing on the development of a novel strategy to access more reactive dimethyl alkenylsiloxanes and their applications. Finally, this new strategy is applied to the synthesis and different approaches to assemble incednam are explored.
Supervisor: Anderson, Edward Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available