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Title: Mapping ENU-induced thymic lymphoma susceptibility loci in C57BL/6 mice
Author: Romao, P. L.
ISNI:       0000 0004 7228 3214
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2017
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Tumour development is a complex process involving susceptibility loci (oncogenes) and the accumulation of spontaneous somatic mutations in tumour suppressor genes that interact to result in cancer. Tumours may require the accumulation of a variety of mutations before developing but the general principle is that the mutations result in an imbalance between the oncogene and tumour suppressor gene function (Berger et al., 2011). This multi-hit process can be tested by subjecting strains of mice susceptible to certain types of tumours to chemical mutagens, thereby inducing further mutations. This technique is used in this study to identify loci resulting in the susceptibility to thymic lymphoma in the C57BL/6J strain in order to further our understanding of the processes involved in the development of such tumours.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (D.V.M.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: RC 254 Neoplasms. Tumors. Oncology (including Cancer)