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Title: Synthesis of benz- and cyclohepta-pyridines
Author: Jones, Ronald K.
Awarding Body: Keele University
Current Institution: Keele University
Date of Award: 1972
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The methods of synthesis of benzocyclohepteneones are reviewed. A sequential Claisen - Dieckmann condensation has been used to prepare di-alkyl 5,9-dihydroxy-7H-cyclohepta-[b]-and-[c]-pyridine-6,8-dicarboxylates. These have been converted to the cyclopropaquinoline and cyclopropaisoquinoline-diones. A review of some of the methods of preparing quinolines and isoquinolines is included. The sequential condensation was adapted to prepare diethyl 5,8-dihydroxyquinoline-6,7-dicarboxylate and diethyl 5,8-dihydroxyisoquinoline-6,7-dicarboxylate which were oxidised to the corresponding quinones. The quinoline-5,8-dione acted as a dienophile with cyclopentadiene. Diels Alder adducts of the pyrido-[2,3-d]-and[3 ,4-d] - pyridazine-1,4-diones have been prepared. 9H-cyclohepta-[b] -pyridine-9-one has been synthesised. Ynamine chemistry is reviewed. The reaction of ynamines with carboxylic acids has been studied. An attempt was made to perform a photochemical cycloaddition using an ynamine.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QD Chemistry