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Title: The role of moisture profiling towards understanding pharmaceutical solid state functionality : validation and the application of a moisture profiling analytical tool for investigation into the characterisation of, and prediction of, the effects of compaction and storage on different lactose physical forms
Author: Seymour, Louise
ISNI:       0000 0004 7227 1977
Awarding Body: University of Bradford
Current Institution: University of Bradford
Date of Award: 2015
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The majority of therapeutic pharmaceutical formulations are presented in the solid form. Moisture is able to play an important role in the functional performance of pharmaceutical solids. Moisture profiling is able to provide novel information with regards to the behaviour of moisture within materials using equilibrium relative humidity as a measurement. The hypothesis investigated explores the changes in equilibrium relative humidity of pharmaceutical material induced by physical, chemical or storage conditions, these are able to be monitored using the innovative moisture profiler system. The aims within this were to primarily validate the moisture profiler and secondly evaluate the effects of moisture on physical forms and with respect to effects of compaction, finally this was compared to conventional characterisation methods. Preliminary explorations were conducted in order to assess the validity of the moisture profiler, from this lactose was selected as a suitable pharmaceutical material for further work. Processing effects were then examined, firstly storage at elevated relative humidity of different forms of lactose were explored, and this was carried out with supplementary analysis. Secondly the effects of tabletting were explored, different compaction forces were investigated to observe if this had any notable effects on equilibrium relative humidity of the different lactose forms. Finally subsequent storage of the compacts were examined in order to explore if there were any changes in the equilibrium relative humidity.
Supervisor: Not available Sponsor: EPSRC ; Reckitt Benckiser
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Moisture profiling ; Equilibrium relative humidity ; Compaction ; Storage stability ; Lactose physical forms ; Solid state properties ; Thermal properties