Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.737923
Title: Neural noise and suppression in visual processing
Author: Vilidaite, Greta
ISNI:       0000 0004 7225 9134
Awarding Body: University of York
Current Institution: University of York
Date of Award: 2017
Availability of Full Text:
Access from EThOS:
Full text unavailable from EThOS. Thesis embargoed until 09 Mar 2023
Access from Institution:
Abstract:
Signal transduction in sensory systems is affected by two major neural mechanisms: neural noise and suppression. Both of these factors present limits on the perceptual abilities of the observer. For example, in contrast discrimination both elevate thresholds. Suppression and neural noise have been implicated in normal sensory development, ageing and several neurological disorders. Of particular interest are autism spectrum conditions (ASCs), in which both neural noise and suppressive mechanisms seem to be atypical. This thesis addresses several issues surrounding the measurement and neural implications of neural noise and suppression. Firstly, it investigates where in the brain neural noise affects sensory processing. Using machine learning algorithms to analyse electro- and magneto-encephalography data, it was found that the main source of neural noise is early sensory cortex. Secondly, it compares psychophysical paradigms used to dissociate the effects of noise and suppression, and suggests refined methods, in particular, using double-pass consistency. Thirdly, it investigates the neural effects of modulating neural noise and suppression selectively using transcranial magnetic stimulation (TMS). It reveals that two existing TMS protocols are suitable for this: single pulses suppress neural signals, whereas triple-pulse TMS increases neural noise. Lastly, the thesis investigates neural noise and gain control (a suppressive mechanism) in ASC. The findings show a relationship between sensory noise and autistic traits in the neurotypical population. Furthermore, electrophysiology data from ASC children and adults as well as a genetic Drosophila model of autism revealed a deficit in the transient dynamics of ASC visual systems, which changes over the course of development. Striking similarities between the fruit fly (Nhe3) model and humans suggests that the genetic model is suitable for further research on ASC sensory symptoms. Taken together, this thesis expands the understanding of neural noise and suppression as well as the situations in which these mechanisms are implicated.
Supervisor: Baker, Daniel ; Wade, Alex R. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.737923  DOI: Not available
Share: