The causes of facial anomalies in children may be congenital, traumatic, oncologic (or in some cases) remain unknown. Many of these craniofacial conditions warrant further elucidation of the clinical features, to allow accurate diagnosis and targeted management. Long term outcome studies of children with craniofacial anomalies, are essential to evaluate treatment protocols and to aid those who treat affected children to improve and advance their standards of care. These objectives require clinicians, along with their scientific colleagues, to strive to increase their recognition of morphological anomalies and understanding of the underlying disease processes, so as to develop specific management strategies. The aim is to find new answers to improve the quality of life of affected children throughout the world. This collection of papers has been prompted by a desire to contribute towards that goal.