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Title: The biochemical properties of drug-resistant mutants of bacteria and other micro-organisms
Author: White, Peter J.
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 1958
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An investigation has been made of the biochemical mechanisms of resistance to sulphonamide drugs in five strains of staphylococci. Resistant strains of micro-organisms for comparative studies are usually derived from sensitive parent organisms by a number of procedures, of which the most frequently used is repeated subcoltivation in the presence of increasing concentrations of inhibitor. There are several possible mechanisms of drug-resistance, and some of these have been demonstrated in sulphonamide-resistant organisms. More is known about the mode of action of the sulphonamides than of most antibacterial substances, and this information directs attention to the metabolism of p-aminobenzoic acid (PAB) and folic acid, where changes seem likely to lead to the development of resistance.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available