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Title: The development of biomarkers for neurodegenerative diseases
Author: Raby, Samantha Jade
ISNI:       0000 0004 6498 9612
Awarding Body: Lancaster University
Current Institution: Lancaster University
Date of Award: 2014
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The accumulation of misfolded proteins to form inclusion bodies and other protein aggregates outside of cells is a pathological hallmark of neurodegenerative diseases. These aggregating proteins represent potential biomarkers of disease that may facilitate disease diagnosis and the development of therapeutic treatments. Currently neurodegenerative diseases are diagnosed clinically using physical, behavioural and memory based tests along with brain imaging techniques. These methods are associated with variable sensitivity and specificity, and at the point of development of physical symptoms a large amount of neuronal damage has already occurred. Protein biomarkers in easily accessible fluids such as plasma and CSF, can provide additional information to aid in earlier diagnosis, therefore allowing treatments to have a better chance of not only alleviating symptoms but slowing disease progression or perhaps halting disease development.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available