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Title: Stereochemical aspects in the aminoalkylation reactions of ketones
Author: Fairhurst, Robin A.
Awarding Body: Loughborough University of Technology
Current Institution: Loughborough University
Date of Award: 1991
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A simple "one-pot" method has been developed for the amino-methylation of ketones possessing an α-hydrogen under aprotic conditions. The procedure utilises chlorotrimethylsilane in the sequential formation of the intermediate trimethylsilyl enol ether and methylene iminium species. The methylene iminium ion intermediate is generated either from a dialkylaminoalkoxymethane or a bis-(dialkylamino)methane.
Supervisor: Not available Sponsor: SERC
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available