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Title: Data acquisition and data analysis in skin measurements
Author: Zhang, Xu
ISNI:       0000 0004 6497 4058
Awarding Body: London South Bank University
Current Institution: London South Bank University
Date of Award: 2017
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The water in skin, particularly in stratum corneum, the outmost skin layer, is very important. However, to measure it is very difficult. OTTER (Opto-thermal transient emission radiometry), AquaFlux, and Epsilon are three novel technologies specifically developed by our research group for such measurements. This thesis describes the latest development of the technologies. The main focus is to develop a state of the art OTTER data acquisition and data analysis software programme based on Pico Technology. The new software programme offers a range of benefits, such as faster sampling rate, better ADC resolutions, more user friendly interfaces, and more functions and features. The modularized dynamic link library based approach, also means it is easier to maintain, update and expand. With the new OTTER software programme, a multiple wavelength detection is carried out, and an enhanced segmented least squares (SLS) fitting is proposed. The results show that by combining multiple wavelength detection and enhanced SLS fitting, OTTER is capable to detect different types of skin damage, and the presence of topically applied solvents as well as depth distribution of solvents within skin. The second main focus is skin characterization by using AquaFlux and Epsilon, as well as other skin measurement instruments, such as Corneometer, Moisture Checker, Hydratest Beauty Pro, and ProscopeHR2 digital microscope. The aims are to have better understanding on the instrument performances, the correlations between instruments, as well as skin damage assessments, and in vitro and in vivo skin solvent penetration. The results show that the combination of AquaFlux and Epsilon can be very useful for skin characterizations, and the ratio of skin hydration and TEWL can be a better index for skin barrier function. The results also show that the Epsilon capacitive occlusion curves can be potentially used for skin damage assessments, as it can detect both the scale of the damage, and the type of the damage. The skin solvent penetration results show that Epsilon can be effectively used for measuring different types of solvents, and a method to quantify solvent concentration in skin has been developed.
Supervisor: Xiao, Perry Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available