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Title: The human immune response to oral vaccination with live-attenuated Salmonella Typhi (Ty21a)
Author: Pennington, S. H.
ISNI:       0000 0004 6496 4378
Awarding Body: University of Liverpool
Current Institution: University of Liverpool
Date of Award: 2017
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Typhoid fever continues to represent a significant threat to global health and currently licensed vaccines confer incomplete protection. In 1975, an oral typhoid vaccine was developed through the chemical mutagenesis of pathogenic Salmonella enterica serovar Typhi strain Ty2. This vaccine, which is designated Ty21a, has been used for many years to combat disease; it is well-tolerated with a cumulative efficacy of approximately 58% up to 2 years following its administration. A great deal of data have been collected concerning peripheral cellular and humoral immune responses to this vaccine; however, only surrogate measures of mucosal immunity exist. The data presented within this thesis demonstrate the value of direct mucosal sampling and provide fresh insight into aspects of human immunity which have not previously been explored. The data presented describe the strength, diversity and duration of mucosal and peripheral cellular immune responses to Ty21a. In addition, the data demonstrate the wider impact of Ty21a on responses to non-related pathogens. Data presented here support the use of direct mucosal sampling to study host-pathogen interaction and the development of S. Typhi based vectors.
Supervisor: Gordon, M. A. ; Ferreira, D. M. ; Gordon, S. B. ; Kadioglu, A. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral