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Title: Molecular and nanoparticle-based multimetallic assemblies for sensing applications
Author: Toscani, Anita
ISNI:       0000 0004 6495 8736
Awarding Body: Imperial College London
Current Institution: Imperial College London
Date of Award: 2016
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Chapter 1 introduces the concept of optical sensing and describes the operation of a molecular-base optical sensor along with its characterising parameters. The photophysical properties and the principal sensing mechanisms of transition metal-based optical sensors are herein explained with detailed examples. Chapter 2 describes the past developments in the field of optical detection of sulfur dioxide. Successively, the synthesis and characterisation of a series of 5-coordinate ruthenium complexes and the preliminary studies on their use for the optical detection of sulfur dioxide are described. The reactivity of the complexes towards sulfur dioxide is also investigated. Chapter 3 provides an overview on the chromo-fluorogenic detection of carbon monoxide in air. The synthesis and characterisation of two series of ruthenium and osmium complexes are reported, together with the results of their use as chromo-fluorogenic sensors for carbon monoxide. The mechanism of sensing, as well as the investigation on the sensitivity and selectivity of these sensors, are discussed and compared. In Chapter 4, the new developments on the detection of carbon monoxide in biological systems are described. The optical sensors described in Chapter 3 are herein adapted in order to be employed in aqueous systems. The synthesis, characterisation and the sensing properties of the resulting metal complexes are reported. The cellular viability and preliminary results on the sensing response of two ruthenium complexes internalised in HeLa cells are also reported. Alternatively to the molecular-based systems previously discussed, a sensing system based on the functionalisation of a novel ruthenium probe on the surface of gold nanoparticles is also investigated. Experimental details related to the synthesis, characterisation and photophysical studies of the compounds in Chapters 2 to 4 are detailed in Chapter 5.
Supervisor: Wilton-Ely, James Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral