The management of Colorectal Cancer has evolved, and in many parts of the world is provided by multidisciplinary teams (MDTs). In the UK all patients with colorectal cancer have their management discussed at MDTs. This thesis presents a series of mixed method studies aimed at developing and utilising methods to evaluate and assess the functioning of Colorectal Cancer MDTs. The introduction presents an overview Colorectal Cancer and the role of MDTs. Chapter 2 presents a systematic review and meta-analysis of studies on Colorectal Cancer MDTs. Chapter 3 explores the views of core members of Colorectal Cancer MDTs on potential assessment tools. Chapter 4 concludes this section with an analysis of the costs involved with these teams. In Chapter 5 I describe the development and validation of an observational tool for evaluation of Colorectal Cancer MDTs, followed by an evaluation of the relationships between decision making within the team and the various aspects of the tool described in Chapter 6. Chapter 7 presents the feasibility of reliably using this tool for video based assessments of Colorectal Cancer MDTs. I conclude this thesis with a general discussion – focussing on relevant findings, clinical implications of my work and directions for future research.