Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.732761
Title: Towards the total synthesis of Ajudazol B
Author: Adair, Liam David
ISNI:       0000 0004 6493 7695
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 2017
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Abstract:
Ajudazol B is a polyketide secondary metabolite, isolated from Chondromyces crocatus in 2002, that exhibits anti-fungal activity through potent inhibition of the electron transport chain. The main objective of the work described in this thesis was to use and expand the oxidative rearrangement of isobenzofurans to generate isochromanones, and apply this towards the total synthesis of ajudazol B. The rearrangement was used as a key step in the synthesis of the full ajudazol B framework. The synthesis was achieved in 20 steps and 11% overall yield. The isomer of ajudazol B was synthesised in 21 steps and 8% overall yield. Its biological activity remains to be determined.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.732761  DOI: Not available
Keywords: QD Chemistry
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