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Title: ISG expression screening reveals the family-specific antibunyaviral activity of ISG20
Author: Feng, Junjie
ISNI:       0000 0004 6499 0453
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 2017
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Order Bunyavirales poses a significant threat to the agricultural industry, animal husbandry and human welfare. In response to viral infections, interferons (IFNs) trigger the expression of numerous interferon stimulated genes (ISGs) whose concerted action can potently inhibit the replication of bunyaviruses. We used a FACS-based method to screen the ability of ~500 unique ISGs from humans or rhesus macaques to inhibit the replication of Bunyamwera virus (BUNV), the prototype of both the Peribunyaviridae family and Bunyavirales order. Candidates possessing antibunyaviral activity were further examined using a panel of divergent bunyaviruses in family Peribunyaviridae, Hantaviridae, Nairoviridae and Phenuiviridae.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QR355 Virology