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Title: Development of coherent Raman scattering microscopy for monitoring drug delivery
Author: Pickup-Gerlaugh, Adam John
ISNI:       0000 0004 6497 2693
Awarding Body: Durham University
Current Institution: Durham University
Date of Award: 2017
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Topical pharmaceuticals are a vitally important part of modern medicine. Currently, characterising the dermatopharmacokinetics of these drugs is very difficult, and not possible in either real-time, or with a high level of accuracy. This thesis applies three coherent Raman scattering microscopy techniques to the challenge of video-rate monitoring of a porcine skin model undergoing penetration by two different, widely used, pharmaceuticals. It was found that the data taken during these time-course experiments could be used in conjunction with a Beer-Lambert expression, and Fick’s second law, to extract valuable permeation data – namely the skin-solute partition coefficient, and diffusion coefficient – of these pharmaceuticals.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available