This thesis has been written in the format of three papers: a systematic review, an empirical paper and a critical reflection paper. Paper one presents a systematic review into the effectiveness of psychological treatments for treatment resistant depression in adults. Paper two presents a qualitative study aimed to explore utility of family liaison meetings in an adult mental health rehabilitation and recovery unit. Paper three presents a critical reflection on the process of conducting the research contained in this thesis and as such is not intended for publication. The implications of the research for clinical practice and the relevance for clinical psychology, and adult psychiatric care are discussed. Reflections on personal and professional development are also explored.