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Title: The effectiveness of pharmacist interventions in improving asthma control and quality of life in patients with difficult asthma
Author: Capstick, Toby Gareth David
ISNI:       0000 0004 6495 2182
Awarding Body: University of Bradford
Current Institution: University of Bradford
Date of Award: 2014
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Despite national guidelines, the management of difficult asthma remains suboptimal, and there may be opportunities for pharmacists to improve asthma outcomes. This six-month prospective, randomised, open study investigated the effects of pharmaceutical care across primary and secondary care on difficult asthma. Fifty-two patients attending a hospital difficult asthma clinic were randomised (1:1) to receive usual medical care (UC), or pharmacist interventions (PI) comprising asthma review, education, and medicines optimisation from a hospital advanced clinical pharmacist, plus follow-up targeted Medicines Use Review (t-MUR) from community pharmacists. Forty-seven patients completed the study. More interventions were performed in the PI group at baseline (total 79 vs. 34, p<0.001), but only six patients received a t-MUR. At six-months, PI were non-inferior to UC for all outcomes. The primary outcome measure was Juniper’s Asthma Control Questionnaire score and reduced (improved) from a median (IQ) score of 2.86 (2.25, 3.25) and 3.00 (1.96, 3.71) in the PI and UC groups respectively to 2.57 (1.75, 3.67) and 2.29 (1.50, 3.50). At baseline, 58.8%, 46.9% and 17.6% of patients had optimal inhaler technique using Accuhalers, Turbohalers or pMDIs; education improved technique but this was not maintained at six-months. Adherence rates < 80% were observed in 57.5% of patients at baseline, and was improved in the PI group at six-months (10/20 PI vs. 3/21 UC had adherence rates of 80-120%, p=0.020). This study demonstrates that the management of difficult asthma by specialist pharmacists is as effective as usual medical care. Future research should investigate whether pharmacist-led follow-up produces further improvements.
Supervisor: Not available Sponsor: Pharmaceutical Trust for Educational and Charitable Objects (PTECO) (Pharmacy Research UK)
Qualification Name: Thesis (D.Pharm.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Asthma ; Pharmacist interventions ; Pharmacist prescribing ; Quality of life ; Asthma control ; Hospital pharmacists ; Community pharmacists ; Care transitions