Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.732034
Title: Synthesis, reactions, and mass spectra of some indolizines
Author: Stanyer, Joseph
Awarding Body: Keele University
Current Institution: Keele University
Date of Award: 1968
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Abstract:
The methods of synthesis and known properties of indolizines are reviewed. A number of indolizine compounds substituted in both the 5 membered and 6 membered rings have been prepared by known synthetic routes. The use of an ion exchange resin to bring about ring closure of an intermediate quaternary compound is described. Reduction with lithium aluminium hydride will usually convert indolizine esters to hydroxymethyl derivatives except in the case of the 1 position where reduction proceeds to the alkyl derivative. Reduction of 2-methyl-7-cyanoindolizine with lithium aluminium hydride gives the expected aminomethyl compound while 2-methyl-6-cyano­indolizine does not. Reduction of the ring system may be occurring. Reduction of indolizine with sodium and ethanol gives a mixture of a dihydro and tetrahydro product; further treatment yields only the tetrahydro product, 5,6,7,8-tetrahyclroindolizine. The mass spectra of indolizine and some of its derivatives are presented and the cracking patterns discussed. A marked similarity between the spectra of monomethylindolizines and monomethylindoles is noted and a possible explanation is put forward.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.732034  DOI: Not available
Keywords: QD Chemistry
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