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Title: Studies on the prebiotic origin of 2-deoxy-D-ribose
Author: Steer, Andrew Mark
ISNI:       0000 0004 6497 8331
Awarding Body: University of York
Current Institution: University of York
Date of Award: 2017
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This research attempts to provide a possible explanation to the chemical origin of 2-deoxy-D-ribose via an aldol reaction of acetaldehyde and D-glyceraldehyde. The sugar mixture is trapped with N,N-diphenylhydrazine for ease of purification and characterisation. The reaction is promoted by amino acids, amino esters and amino nitriles consistently giving selectivities in favour of 2-deoxy-D-ribose. This is the first example of an amino nitrile-promoted reaction. The research is developed further by exploring the formation of 2-deoxy-D-ribose in a "protocell" environment - a primitive cell. Here we suggest that primitive cells may have been simple hydrogel systems. A discussion of the characterisation and catalytic ability of small peptide-based structures is included.
Supervisor: Clarke, Paul ; Smith, David Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available