Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.731584 |
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Title: | Studies on the prebiotic origin of 2-deoxy-D-ribose | ||||||
Author: | Steer, Andrew Mark |
ISNI:
0000 0004 6497 8331
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Awarding Body: | University of York | ||||||
Current Institution: | University of York | ||||||
Date of Award: | 2017 | ||||||
Availability of Full Text: |
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Abstract: | |||||||
This research attempts to provide a possible explanation to the chemical origin of 2-deoxy-D-ribose via an aldol reaction of acetaldehyde and D-glyceraldehyde. The sugar mixture is trapped with N,N-diphenylhydrazine for ease of purification and characterisation. The reaction is promoted by amino acids, amino esters and amino nitriles consistently giving selectivities in favour of 2-deoxy-D-ribose. This is the first example of an amino nitrile-promoted reaction. The research is developed further by exploring the formation of 2-deoxy-D-ribose in a "protocell" environment - a primitive cell. Here we suggest that primitive cells may have been simple hydrogel systems. A discussion of the characterisation and catalytic ability of small peptide-based structures is included.
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Supervisor: | Clarke, Paul ; Smith, David | Sponsor: | Not available | ||||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||||
EThOS ID: | uk.bl.ethos.731584 | DOI: | Not available | ||||
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