Use this URL to cite or link to this record in EThOS:
Title: A new framework for right-first-time production of granules and tablets : a systems engineering approach to modelling and optimization
Author: Al Alaween, Wafa'
ISNI:       0000 0004 6497 738X
Awarding Body: University of Sheffield
Current Institution: University of Sheffield
Date of Award: 2018
Availability of Full Text:
Access from EThOS:
Access from Institution:
In this research, the concept of 'right-first-time' production of the granules and tablets is achieved via a systems-engineering based approach. The research has been undertaken via two different but synergising phases. In the first phase, various modelling frameworks based on data, process knowledge and laws of physics are proposed to represent the most critical operations (i.e. granulation and tabletting) of the tablet production line. In the second phase, these modelling paradigms are exploited in a reverse-engineering framework in order to identify the optimal operating conditions to produce a tablet with predefined properties. Therefore, a new approach that embeds constrained multi-objective optimization algorithms is presented to facilitate the implementation of the reverse-engineering framework by which the concept of 'right-first-time' production is achieved. All the proposed modelling and optimization paradigms are successfully validated via real laboratoryscale experiments, where the granules and tablets are successfully produced right from the first time, and also the waste and recycling ratios are significantly minimized.
Supervisor: Mahfouf, Mahdi ; Salman, Agba Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available