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Title: Synthesis, study and application of NHC-gold(I) complexes
Author: Veenboer, Richard M. P.
ISNI:       0000 0004 6498 8820
Awarding Body: University of St Andrews
Current Institution: University of St Andrews
Date of Award: 2017
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The development of procedures for the synthesis of valuable organic molecules constitutes an important part of chemistry. The goal of improving the efficiency of existing methodologies can be fulfilled by use of metal catalysts. Recent developments in the field of homogeneous gold catalysis have contributed to these efforts and continued investigations assure future innovations. Chapter 1 summarises the properties of gold and ligand-supported gold(I) complexes and demonstrates how a detailed understanding of its reactivity and possible bonding interactions with various substrates facilitates the development of well-defined catalytic systems. Particular attention is given to N-heterocyclic carbenes, highly tunable ligands that stabilise a wide range of different transition metal complexes. Three chapters describe syntheses and studies of known and new complexes. Chapter 2 discusses expedient syntheses of key NHC-gold(I) complexes and catalysts. Chapter 3 constitutes studies to the behaviour of the commonly used tetrafluoroborate counterion in a particular IPrCl -gold(I) complex. Chapter 4 de- scribes the synthesis of a range of IPr-gold(I) carbanion complexes from the widely studied IPr-gold(I) hydroxide synthon, the study of their properties and exploration of their reactivity. Catalytic applications in transformations of alkynes and alcohols are described in the last three chapters. Chapter 5 details the development of efficient NHC-gold(I)-catalysed procedures for the synthesis of vinyl ethers through addition reactions of aliphatic and benzylic alcohols to alkynes. Benzylic alcohols were found to undergo gold-catalysed dehydration under specific conditions and Chapter 6 discloses the NHC-gold(I)-catalysed dehydrative formation of ethers from phenols and benzylic alcohols. Appendix A describes preliminary explorations to the complimentary use of Brønsted acidic compounds as catalysts for the formation of products with new C – C bonds from benzylic alcohols and phenols.
Supervisor: Nolan, Steven P. ; Cazin, Catherine Suzanne Julienne ; Goss, Rebecca J. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Gold ; NHC ; Organometallic ; Homogeneous ; Catalysis ; Complexes ; QD505.V44 ; Gold compounds ; Complex compounds ; Metal catalysts