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Title: Cyclic alkenylsiloxanes : synthesis and application towards incednam
Author: Gudmundsson, Haraldur
ISNI:       0000 0004 6495 2131
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2016
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This thesis explores the use of cyclic alkenylsiloxanes in Hiyama cross-coupling reactions for the stereospecific construction of the Z-pentaenyl system of incednam, the aglycon of incednine. The early chapters continue the investigation of the previously developed C6-C13 lynchpin cyclic diethyl alkenylsiloxane, accessed by controlled semi-hydrogenation of alkynylsiloxane. Later chapters discuss the development of a novel strategy to access the more reactive cyclic dimethyl alkenylsiloxanes and their application towards the synthesis of incednam.
Supervisor: Anderson, Ed Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available