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Title: Simultaneous, non-invasive measurements of skin blood flow and oxygenation in healthy humans
Author: Kuliga, Katarzyna Zofia
ISNI:       0000 0004 6496 2065
Awarding Body: University of Southampton
Current Institution: University of Southampton
Date of Award: 2016
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Adequate blood flow within microcirculation and sufficient tissue oxygenation are essential for tissue health. However, the quantitative understanding of dynamics between the microvascular blood flow and oxygenation remains limited. The aim of this study was to explore and interpret simultaneous measurements of skin blood flux (BF) and oxygenation parameters (OXY) recorded from healthy skin. Measurements were recorded using a recently developed (Moor Instruments Ltd, UK) combined Laser Doppler Flowmetry (LDF) and White Light Spectroscopy (WLS) technique, which offer an easy to perform assessment of skin microcirculation and skin oxygenation. In this thesis, two open studies have been conducted in cohorts of healthy volunteers to evaluate combined LDF-WLS measurements and to study the relationship between skin BF and OXY. The engineering challenge of this thesis was to apply signal processing methods to analyse BF and OXY parameters and to extract information that reflect the physiological characteristics of the tissue. Signal processing methods such filtering, convolution, Fourier transform and others served as tools to identify different properties of the signals and subsequently describe the biological systems. The measurements acquired across wide range of values led to mathematical description of the relationship between skin BF and oxygenation and revealed different oscillatory characteristics in BF and OXY signals. The analysis showed resting BF and OXY signals have the highest coherence across low frequency bands. Furthermore, OXY signals are delayed in respect to BF signals. Signal obtained during thermally induced vasodilation showed a shift in signal power to the cardiac frequency band. In conclusion, simultaneous measurements of skin BF and OXY signals in combination with signal processing techniques offer an extended assessment of microvascular function, which may complement clinical assessment of tissue status. Further work is now required to combine presented in this thesis BF and OXY characteristics with other available analysis into clinically useful assessment.
Supervisor: Clough, Geraldine Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available