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Title: Studies into iridium-catalysed asymmetric allylic alkylation towards the total synthesis of a dolabellane
Author: Jiang, Lingfan
ISNI:       0000 0004 6497 7275
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2016
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In recent years, iridium-catalysed asymmetric allylic substitution has received considerable attention because it is a valuable tool to selectively synthesise chiral compounds with high ee from simple starting materials. This thesis presents an efficient catalytic system for the decarboxylative iridium-catalysed asymmetric allylic alkylation (AAA) in which a wide range of allylic β-ketoester substrates was converted into chiral ketones in good yields with high regio- and enantioselectivities. A possible mechanism for decarboxylative iridium-catalysed AAA is also proposed in this thesis.
Supervisor: Burton, Jonathan Sponsor: Agency for Science Technology and Research
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available