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Title: Amniotic membrane transplantation & the role of spongy layer
Author: Suleman, Mohammed Hanif Jamal
ISNI:       0000 0004 6496 2946
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2015
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Amniotic membrane transplantation (AMT) has gained momentum as a useful tissue in the treatment of blinding ocular disorders. However, its extensive use lacks an evidence base. One of the layers of amniotic membrane (AM), the spongy layer (SL), is a tissue that only has relevance to ocular surgeons, when it hydrates excessively and impedes application of AM on to the ocular surface and consequently is invariably removed. This research critically assessed the effectiveness of AMT in the ophthalmic clinical arena and showed that the procedure was equivalent in effectiveness to medical alternatives. Furthermore, lower maternal age and male gender of the fetus were associated with successful AMT outcome in stem cell related disorders. Investigation of the SL revealed that lower maternal age and male gender of fetus were associated with higher levels of migration inhibition factor (MIF) and lower levels of MMP10 in the SL, respectively. Therefore, the levels of these SL factors may help explain AMT outcomes. In addition to these factors, the SL contains a host of 'useful ocular healing factors' that could be manipulated into narrow therapeutic levels in preparation for a potential ocular medicament. Much further work remains to try to improve AMT outcomes and prevent the global burden of blindness. Screening of donors of AM may contribute to more uniform tissue and hence more predictable outcomes. Also, the SL appears to contain a host of factors considered beneficial for ocular healing. This finding is very much in its infancy as a potential ocular therapeutic substance.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available