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Title: Copper-catalysed silicon and boron functionalisation of heterocycles and allenes
Author: Rae, James
ISNI:       0000 0004 6494 9979
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2015
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Silicon holds a privileged position in organic chemistry as the carbon-silicon bond can be utilised in many important transformations. As such, developing practical and efficient methods for the enantioselective and regioselective insertion of silicon into organic molecules is a worthy challenge in chemical synthesis. To this end, we have developed an affordable copper-catalysed protocol for the asymmetric silylation of lactones, lactams and amides, providing silylated products with up to > 99:1 er and in good yields. Furthermore, we have demonstrated the synthetic utility of this protocol in the target synthesis of natural or biologically active molecules. We also present the first copper-catalysed silylation of allenes using a silylborane reagent. This affords useful allyl- or vinylsilane building blocks with high regioselectivity, efficiency and a large functional group tolerance. The allylcopper intermediates can be intercepted by aldehydes in a diastereoselective three-component coupling to furnish homoallylic alcohols. We extend this concept to the copper-catalysed three-component coupling of boron, allenes and imines, providing access to homoallylic amines with a vinylborane motif.
Supervisor: Procter, David Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Catalysis ; Allene ; Boron ; Copper ; Enantioselective ; Silicon