Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.727511 |
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Title: | Synthesis and evaluation of cationic lipids for gene delivery | ||||
Author: | Maginty, Amanda Bronagh |
ISNI:
0000 0004 6425 0420
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Awarding Body: | Queen's University Belfast | ||||
Current Institution: | Queen's University Belfast | ||||
Date of Award: | 2017 | ||||
Availability of Full Text: |
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Abstract: | |||||
This thesis entails the synthesis and in vitro evaluation of a number of cationic lipids.
These lipids include those with a dimethylamine (DMA) headgroup or trimethylamine (TMA) headgroup, a seven or eleven carbon chain length or a mixed carbon chain length within the hydrophobic domain. The lipids are characterised by acyclic or macrocyclic hydrophobic regions that are either saturated or unsaturated.
The work describes the successful synthetic routes to these various different cationic lipids and looks at the biological effects that are had on toxicity, transfection and DNA binding, when the various different structural aspects of the cationic lipids are changed.
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Supervisor: | Not available | Sponsor: | Not available | ||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||
EThOS ID: | uk.bl.ethos.727511 | DOI: | Not available | ||
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