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Title: Effect of vitamin D₃ supplementation on cardiovascular disease risk factors in a population with prediabetes
Author: Holmes, Lauren
ISNI:       0000 0004 6424 5699
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2017
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Lower vitamin D status has been associated with an increased risk of developing type 2 diabetes. As insulin resistance is present in people with type 2 diabetes and those with prediabetes, and Is a known risk factor for hypertension and CVD: improved insulin resistance has the potential to reduce the risk of CVD. The primary aim of this thesis was to examine the effect of vitamin D supplementation on CVD risk factors in those with prediabetes and a suboptimal vitamin D status. A double blind placebo, controlled, randomised controlled trial, was carried out using 3,0001U/day vitamin D3 for six months. Results showed no significant change in clinical blood pressure, ambulatory blood pressure, any indicators from pulse wave analysis, pulse wave velocity or CVD related inflammatory markers between groups. In a subset of the population, further measurements were carried out to examine the effect of vitamin D supplementation on other markers of health such as handgrip strength, quality of life, infections and pain; no signficant changes were seen in any of the markers.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available