Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.727117 |
![]() |
|||||
Title: | Impact of toxin-antitoxin systems, intracellular proteases and major regulatory networks on Pseudomonas aeruginosa persistence | ||||
Author: | Garavaglia, Marco |
ISNI:
0000 0004 6423 3815
|
|||
Awarding Body: | University of Nottingham | ||||
Current Institution: | University of Nottingham | ||||
Date of Award: | 2015 | ||||
Availability of Full Text: |
|
||||
Abstract: | |||||
Bacterial Type II toxin—antitoxin (TA) protein pairs are encoded by adjacent, co-transcribed genes. Most of the toxins belonging to such systems function as endoribonucleases (mRNases), decreasing the half-lives of mRNAs and consequently the global translation rate in bacterial cells, although toxins with other mechanisms of action have also been described. The activity of these proteins is modulated by antitoxins that counteract the growth inhibitory effect of their cognate toxins by direct protein-protein interactions. Toxins are far more stable than their relative antitoxins as the latter are rapidly degraded by intracellular proteases, in response to environmental and physiological stresses (e.g. amino acid starvation).
|
|||||
Supervisor: | Not available | Sponsor: | Not available | ||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||
EThOS ID: | uk.bl.ethos.727117 | DOI: | Not available | ||
Share: |