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Title: The effectiveness of homeopathic Arsenicum album in the treatment of oral lichen planus
Author: Crawford, Fiona Carole
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2009
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Oral lichen planus(OLP) is a chronic mucosal condition commonly encountered in Oral Medicine departments. It can cause patients significant discomfort, and only a small percentage, undergo complete remission. Recalcitrant lesions can be treated with various systemic medications including steroids. There is to date only weak evidence to suggest that these treatments are superior to placebo. This study was performed to determine whether homeopathic arsenicum album is useful in the treatment of OLP. A randomised double-blind clinical trial comparing homeopathic arsenicum album with placebo was carried out in the oral medicine department of the Edinburgh Dental Institute. The study covered a six-week period and ninety four patients participated. They were randomly assigned to a 6c homeopathic preparation of arsenicum album or to placebo, with all participants receiving placebo for the first week. After a pre-treatment visit, clinical review took place two and six weeks after commencing therapy. The same clinician scored the extent of the oral condition at all visits, and alleviation of symptoms was evaluated using a visual analogue scale diary and the Glasgow Homeopathic Hospital outcome scale. Ninety-two patients completed the study. No significant difference between the groups was seen on the visual analogue scores and there was no significance difference between the two groups with regard to response to treatment. However patients who were good prescribers for arsenicum album did show a difference between the groups with regard to response to treatment, which although not achieving statistical significance was strongly suggestive of an association. In conclusion homeopathic arsenicum album may be useful in the treatment of OLP, but more extensive studies need to be performed.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (D.D.S.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available