Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.721011 |
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Title: | Applications of copper-boryl reagents in synthesis | ||||||
Author: | Hemming, David |
ISNI:
0000 0004 6351 2580
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Awarding Body: | Durham University | ||||||
Current Institution: | Durham University | ||||||
Date of Award: | 2017 | ||||||
Availability of Full Text: |
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Abstract: | |||||||
Previous work into the copper catalysed borylation of alkenyl halides has resulted in the synthesis of cyclic Bpin esters. To date however, the reaction has not been applied to the synthesis of saturated heterocycles nor substituted carbocycles. An overview of the literature precedent for reactions involving copper-boryl complexes is provided in the introduction (chapter 1). Investigations into the reaction were undertaken in an attempt to further expand its scope, and the second chapter outlines preliminary results and investigations into the formation of carbocyclic boronate esters. Application of the borylative cyclisation reaction towards the synthesis of heterocyclic boronate esters is also discussed. The third chapter outlines the development of a copper-boryl mediated deallylation reaction, which was developed as a novel method for the selective deprotection of aryl allyl ethers. Attempts to synthesise chromanyl boronate esters are described in chapter 4,followed by conclusions (chapter 5) and experimental data (chapter 6).
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Supervisor: | Not available | Sponsor: | Not available | ||||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||||
EThOS ID: | uk.bl.ethos.721011 | DOI: | Not available | ||||
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