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Title: Functional connectivity of the ageing brain
Author: Goldstone, Aimée
ISNI:       0000 0004 6350 0889
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2017
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This thesis investigated the impact of advancing age on modifying the functional connectivity (FC) of both typical cortical resting-state networks and subcortical structures in the human brain. Furthermore, it explored how any differences in FC may be associated with changes in sleep quality, also thought to be affected by age, and how such interactions may contribute to typical cognitive disruption associated with older age. The results suggest that older age is associated with the heterogeneous, spatially specific re-organisation of resting-state networks (RSNs), as well as indicating gender-specific spatial re-organisation. Investigation of thalamic FC revealed that older adults exhibited greater thalamo-sensory and thalamo-hippocampal FC, which was related to cognitive performance on RT and memory tasks, respectively. Investigation into participant’s sleep patterns provided evidence that sleep quality was more variable amongst the older participants. Furthermore, older adults that slept the longest each night were found to exhibit patterns of thalamic FC which were associated with better cognitive performance, than seen in older shorter sleepers. These results provide preliminary evidence that sleep may be associated with more ‘preferable’ patterns of FC in older adults which may be beneficial for cognitive function.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: BF Psychology