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Title: Structure/function analysis of hRme-6, a rab5 GEF that integrates trafficking and signaling
Author: Zhu, Zhou
ISNI:       0000 0001 2428 9732
Awarding Body: University of Sheffield
Current Institution: University of Sheffield
Date of Award: 2017
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There is increasing understanding that endocytosis and signalling are linked to each other. Signalling receptors are particularly interesting as cargoes which are precisely regulated through the process of endocytosis. However it is still not clear that how the overlap between endocytosis and signalling occurs mechanistically. Rme-6, a Rab5 GEF, is a potential candidate that is involved in the endocytosis of transferrin and EGFR and also the signalling pathway of Ang1-Tie2. The objective of this thesis was to investigate the structure/function relationship of hRme-6 to understand how it integrates trafficking and signalling processes.
Supervisor: Smythe, Elizabeth Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available