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Title: Opioids, decision-making and sex : a cross-over trail of the abuse-related effects of oxycodone and morphine
Author: Phillips, C.
Awarding Body: UCL (University College London)
Current Institution: University College London (University of London)
Date of Award: 2006
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In the following paper I aim to provide a review of the literature relevant to this research topic. I begin with a summary of prescription opioids and their use in treatment for pain. I follow with a discussion about opioid misuse and abuse and recent epidemiological research. I review current knowledge about addiction and drug dependency, including recent psychological theories and models of addiction. I also provide an examination of studies which have investigated cognitive impairments associated with drug use, with particular emphasis on deficits in decision-making. Following this, I consider differences in abuse potential between drugs, particularly in light of recent concerns about increases in oxycodone abuse. I highlight gaps in the literature regarding the acute rewarding properties of opioids in non-drug abusing humans. I conclude the review with a rationale for the present study investigating the acute effects and abuse-liability of oxycodone compared to morphine in non-drug abusing healthy volunteers.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available