Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.717390 |
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Title: | A mutational analysis of Polyoma virus large T-antigen | ||||||
Author: | King, David Joh | ||||||
Awarding Body: | University of London | ||||||
Current Institution: | Imperial College London | ||||||
Date of Award: | 1988 | ||||||
Availability of Full Text: |
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Abstract: | |||||||
Polyoma virus (PyV) is a murine papovavirus which induces neoplasia via the
concerted action of three T- (tumour-) antigens. The lOOkD PyV large T-antigen
(LT) is a multifunctional protein involved in several aspects of the lytic or
transforming behaviour of the virus. LT is absolutely required for viral DNA
replication, and is also a transcriptional regulator, repressing its own
transcription, and activating the PyV late transcription unit, as well as several
other promoters of viral and cellular origin. LT is able to immortalise primary
rodent fibroblasts, co-operates with the PyV middle and small T-antigens to
induce full transformation, and reduces cellular growth factor requirements.
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Supervisor: | Not available | Sponsor: | Not available | ||||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||||
EThOS ID: | uk.bl.ethos.717390 | DOI: | Not available | ||||
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